Endocrine Abstracts

The pseudo-Cushing’s syndrome that accompanies both acute alcohol ingestion and alcohol withdrawal is an important differential diagnosis of hypercortisolism that is poorly understood. Two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) interconvert hormonally active cortisol (F) and inactive cortisone (E). Previously we have shown higher urinary F:E metabolite ratios (a reflection of total body 11βHSD activity) in patients with alcoholic liver disea...

Objective: Various effects of glucocorticoids occur in brown adipose tissue depending on their duration of action. As a result of exposure to glucocorticoids, thermogenesis and oxygen use in brown fat tissue are reduced in animal studies. In this study, we aimed to compare the levels of UCP1 (uncoupling protein 1), Irisin, BMP 7 (bone morpogenic protein), PRDM16, which are brown addipose tissue markers, between patients with Cushing’s disease and healthy controls<p c...

In the 27 families with FNAH the onset of hyperthyroidism varies from 18 months to 60 years. Also the manifestation of goiters is variable in these families.A 74 year old women first presented at the age of 69 years in 9/2006 with tachyarrythmia and hypertension. After the initial treatment of her hypertension and oral anticoagulation for her intermittant atrialfibrilation 3/2007 a thyroid workup revealed a suppressed TSH of 0.029 (normal< 0.4 mU/l) ...

Adrenal incidentalomas are referred as clinically silent adrenal masses discovered incidentally during diagnostic testing or treatment for conditions not related to suspicion of adrenal disease. Certain percent of them are hormonally active and autonomous cortisol secretion is reported with increasing frequency. The aim of the study was to assess value of 1mg-DST in subclinical Cushing’s syndrome (CS) compared to the other forms of adrenal incidentalomas. We have evaluate...

Introduction: Type 2 diabetes mellitus have been associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress. Meta-analyses have indicated that deletion of either GSTM1 or GSTT1 is associated with a significant increased risk of coronary heart disease. The aim of this study was to evaluated if ascorbic acid (AA) plasma levels differ by GST genotype in d...

Introduction: The most important feature of bone metabolism in patients with Cushing’s syndrome is the uncoupling of osteoblast and osteoclast activity resulting in suppressed bone formation.Objective: The aim of the present study was to investigate the altered bone turnover in patients with various forms of Cushing’s syndrome in the active phase of the disease as well as after successful normalization of cortisol overproduction.<p class="a...

Objectives: To describe the results of the bilateral inferior petrosal sinus sampling (BIPSS) performed in our hospital for differential diagnosis between Cushing disease (CD) and ectopic ACTH secretion (EAS), and evaluate if CRH stimulation during this test improves its diagnostic accuracy.Material and Methods: We retrospectively review 29 BIPSS performed in 26 patients (4 men, 22 women), with mean age of 44.7 year-old (range 28–69), diagnosed wit...

Carney’s Triad is a rare syndrome, with fewer than 30 cases reported with all three tumors (Gastrointestinal stromal tumor, extra-adrenal paraganglioma and pulmonary chondroma) present, and less than 100 cases with two of the three tumor types.We report a 45 yr old female who presented with bloating, dizziness, sweating and palpitations. Physical examination was unremarkable. Biochemistry showed a normal hormonal profile, 24 hrs urinary catecholamin...

IntroductionVarious direct and indirect mechanisms by which glucocorticoid (GC) excess and elevated adrenocorticotropic hormone (ACTH) levels impairs bone metabolism have been described. In the literature, there are different factors described which affect the early outcome of pituitary surgery in patients with CD including preoperative ACTH levels and the clinical severity of the disease. Combining these data, we conducted a retrospective study to inves...

BackgroundResidual adrenocortical function (RAF) is present in one third of patients with autoimmune Addison’s disease (AAD), yet its clinical significance remains unknown.ObjectiveTo investigate if biomarker profiles of cardiovascular disease and inflammation are different in patients with AAD and RAF compared to patients without RAF and healthy controls.Material and methods<p...